The impact of the complement receptors C3aR1 and C5aR1 on the progression of melanoma

Abstract Melanoma is an aggressive skin cancer that develops from the malignant transformation of pigment-producing cells, melanocytes. The incidence cutaneous melanoma remarkably high, with estimated number new cases in United States 2022 close to 100,000 patients. Several previous reports pointed out effect complement system progression melanoma, although precise mechanism largely unknown. a crucial component innate immunity, and it also has significant role adaptive immunity regulating function immune cells. receptors C3aR1 C5aR1 are present on surface various Anaphylatoxins (C3a C5a) generated by activation bind their respective receptors, C5aR1, suppress antitumor cells promote migration activity immunosuppressive tumor microenvironment. Hence, act as checkpoint receptors. To identify we challenged C3 −/−, −/−mice B16F10 murine We showed deficiency these molecules substantially delayed growth promoted antitumorigenic response. results this study indicate distinct receptor signaling suggest novel immunotherapeutic approach. Developmental Research Program Award MD Anderson SPORE (P50CA221703-04)